Section: New Results

Differential diagnosis between atypical Parkinsonian syndromes

Participants : B. Das , K. Daoudi , J. Kemplir , J. Rusz .

In the early stage of disease, the symptoms of Parkinson's disease (PD) are similar to atypical Parkinsonian syndromes (APS). The early differential diagnosis between PD and APS and within APS is thus a very challenging task. It turns out that speech disorder is an early and common symptom to PD and APS. The goal of research is to develop a digital marker based on speech analysis in order to assist the neurologists in their diagnosis. We addressed the problem of differential diagnosis between two APS, Progressive Supranuclear Palsy (PSP) and Multiple System Atrophy (MSA). Using linear discriminant analysis we designed an hypokinetic and an ataxic dysarthria measure which yield a discrimination between PSP and MSA with a high accuracy (88%). This result indicates that hypokinetic and ataxic dysarthria convey valuable discriminative information when mutually considered.

Publication: ICASSP 2019 HAL